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Hydrocodone-Acetaminophen is a prescription combination medication used to relieve moderate to severe pain. It contains:
Hydrocodone: An opioid analgesic (narcotic) that alters pain perception in the brain.
Acetaminophen (Tylenol): A non-opioid pain reliever that also helps reduce fever.
⚠️ Not recommended for children under 6 years of age due to a higher risk of serious respiratory side effects, including slow or shallow breathing.
Read the Medication Guide and Patient Information Leaflet provided by your pharmacist each time you refill.
Ask your doctor or pharmacist if you have any questions.
Take by mouth, as prescribed by your doctor.
Can be taken with or without food. If nausea occurs, taking it with food may help.
For nausea relief, lying down for 1–2 hours with minimal head movement may also help.
Important: If using the liquid form, always measure with a medical measuring device—not a household spoon, as this could lead to incorrect dosing.
Dosing is based on your medical condition, response to treatment, and in children, weight.
Do not exceed the prescribed dosage or take the medication more frequently or for longer than instructed.
Do not abruptly stop taking the medication without your doctor’s guidance.
Pain medications work best when taken at the first signs of pain, rather than waiting until the pain becomes severe.
If you experience chronic pain (e.g., from cancer), your doctor may prescribe long-acting opioids for baseline relief and use this combination product for breakthrough pain. Other non-opioid pain relievers such as ibuprofen or naproxen may be added. Always consult your healthcare provider before combining medications.
Stopping this medication suddenly can lead to withdrawal symptoms such as:
Anxiety, insomnia, mood changes
Nausea, diarrhea, sweating
Muscle aches, watery eyes, runny nose
Your doctor may gradually reduce your dosage to prevent withdrawal.
Long-term use may reduce effectiveness. If your pain worsens or relief is insufficient, notify your doctor.
Hydrocodone carries a risk of addiction, particularly in those with a personal or family history of substance use disorder. To minimize this risk:
Take the medication exactly as prescribed
Never share your medication with others
Keep it out of reach of children and store securely
Speak to your doctor about any concerns regarding dependence or misuse.
Seek medical advice if:
Your pain worsens or persists despite medication
You experience side effects or signs of dependency
You have difficulty breathing or show signs of overdose