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Tramadol is a prescription pain reliever that acts on the central nervous system. It is used to manage moderate to moderately severe pain in adults and mimics the effects of narcotics, though it is technically classified as a synthetic opioid.
There are two primary forms of tramadol:
Immediate-release tablets for quick pain relief.
Extended-release formulations (e.g., Ultram ER, ConZip) designed for around-the-clock pain management. Extended-release tramadol is not intended for as-needed pain relief.
Tramadol can trigger seizures, particularly at high doses or when combined with certain medications such as antidepressants or other opioids. Individuals with a history of seizure disorders are especially at risk.
This medication is habit-forming and may lead to addiction, overdose, or even death, especially if misused or taken without medical supervision.
WARNING: Tramadol should not be used if you have suicidal thoughts, substance use disorder, or serious respiratory issues.
Have severe asthma or breathing difficulties
Have a gastrointestinal blockage
Recently consumed alcohol, sedatives, tranquilizers, or narcotics
Used an MAO inhibitor (e.g., isocarboxazid, selegiline, phenelzine) in the past 14 days
Taking tramadol during pregnancy may result in neonatal opioid withdrawal syndrome, a potentially life-threatening condition for the newborn. Do not breastfeed while using tramadol, as the drug can pass into breast milk and cause severe respiratory depression or death in infants.
Tramadol is not approved for:
Children under 12 years old
Adolescents under 18 years old following tonsil or adenoid surgery
Children aged 12–18 with breathing disorders
Liver or kidney disease
Mental illness, depression, or suicidal behavior
Head injuries or seizures
Gallbladder, pancreas, or thyroid issues
Urinary problems or stomach disorders
Follow your doctor’s instructions exactly. Tramadol should be taken:
With or without food, but consistently in the same manner
Only in prescribed dosages—never increase your dose without medical approval
Swallowed whole (especially extended-release tablets or capsules). Do not crush, chew, or inject the drug. Doing so can cause a lethal overdose.
Stop any other opioid medications before starting tramadol.
Never share this medication with others, especially children or individuals with a history of substance abuse.
Do not abruptly stop taking tramadol. Tapering off the medication under medical supervision is essential to avoid withdrawal symptoms.
Store securely at room temperature, away from moisture and heat. Keep out of reach of children.
Dispose of leftovers properly. One accidental dose could be fatal to someone not prescribed the drug. Utilize a drug take-back program or follow FDA instructions to flush it safely.